Reversing the Damage Caused by Traumatic Brain Injuries

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Come learn with us as we delve into the topic of traumatic brain injuries (TBI’s) and their prevalence. In this informative video, we will explore what TBI’s are, brain inflammation (swelling), how our brains mitigate inflammation, and reasons why our brains struggle to reduce inflammation effectively.

Next, we will take a closer look at a recent research paper published in Nature Immunology, which presents a new therapeutic approach to reduce brain inflammation. During the video, we will examine the background information, methods, and conclude with the results of the paper.

It’s important to note that although this research shows promise in reducing brain inflammation, it’s still in its early stages and has not been approved by the FDA or tested through clinical trials. We want to acknowledge this fact.

This video was made by McMaster University students Fatima Arshad, Ashleen Parmar, Chaandini Ranganathan, and Nabeel Mubasher in collaboration with the Demystifying Medicine McMaster Program.

This video is for general and educational purposes only. Please consult your healthcare provider for information about your health.

Copyright McMaster University 2023

#traumaticbraininjury #Interleukin-2 #T-cells #Adeno-associatedviral ector

References:

​​5 Essential Facts About Traumatic Brain Injuries – Optometrists.org. (n.d.). Retrieved March 6, 2023, from https://www.optometrists.org/vision-therapy/neuro-optometry/vision-and-brain-injuries/traumatic-brain-injury-and-neuro-optometry/5-essential-tbi-facts-you-may-not-know/

​Brain Injury – Injury Lawyers of Ontario. (n.d.). Retrieved March 6, 2023, from https://www.ilolaw.ca/brain-injuries

​Georges, A., & Das, J. M. (2022). Traumatic Brain Injury. Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition, 443–455. https://doi.org/10.1016/B978-0-323-85654-6.00010-1

​Harnessing the immune system to treat traumatic brain injury in mice: Pioneering new treatment leads to improved recovery from brain trauma in mice — ScienceDaily. (n.d.). Retrieved March 6, 2023, from https://www.sciencedaily.com/releases/2022/05/220526112749.htm

​Hope for patients with traumatic brain injury | AAMC. (n.d.). Retrieved March 6, 2023, from https://www.aamc.org/news-insights/hope-patients-traumatic-brain-injury

​Traumatic brain injury – Symptoms and causes – Mayo Clinic. (n.d.). Retrieved March 6, 2023, from https://www.mayoclinic.org/diseases-conditions/traumatic-brain-injury/symptoms-causes/syc-20378557

​Vigil, F. A., Bozdemir, E., Bugay, V., Chun, S. H., Hobbs, M. A., Sanchez, I., Hastings, S. D., Veraza, R. J., Holstein, D. M., Sprague, S. M., M Carver, C., Cavazos, J. E., Brenner, R., Lechleiter, J. D., & Shapiro, M. S. (2020). Prevention of brain damage after traumatic brain injury by pharmacological enhancement of KCNQ (Kv7, “M-type”) K+ currents in neurons. Journal of Cerebral Blood Flow and Metabolism, 40(6), 1256–1273. https://doi.org/10.1177/0271678X19857818

​Why use the mouse in research? – YourGenome. (n.d.). Retrieved March 6, 2023, from https://www.yourgenome.org/facts/why-use-the-mouse-in-research/

​Yshii, L., Pasciuto, E., Bielefeld, P., Mascali, L., Lemaitre, P., Marino, M., Dooley, J., Kouser, L., Verschoren, S., Lagou, V., Kemps, H., Gervois, P., de Boer, A., Burton, O. T., Wahis, J., Verhaert, J., Tareen, S. H. K., Roca, C. P., Singh, K., … Liston, A. (2022). Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation. Nature Immunology, 23(6), 878–891. https://doi.org/10.1038/S41590-022-01208-Z

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Comments

@LiberatedMind1 says:

My brother in law had a severe head trauma incident years ago, he still has delayed and slowed speech.

@andrewhall7176 says:

I had a TBI several years ago, so this video is of great interest to me.

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